Reactive Metabolites and AGE/RAGE-Mediated Cellular Dysfunction Affect the Aging Process – A Mini-Review

The aging cardiomyocyte: a mini-review.

BACKGROUND Aging per se is a risk factor for reduced cardiac function and heart diseases, even when adjusted for aging-associated cardiovascular risk factors. Accordingly, aging-related biochemical and cell-biological changes lead to pathophysiological conditions, especially reduced heart function and heart disease. OBJECTIVE In this review, we summarize the changes that occur as the heart ag...

Sclerostin and Bone Aging: A Mini-Review.

Sclerostin, mainly produced by osteocytes, is now considered a major regulator of bone formation. Identified from patients with a low bone mass, sclerostin inhibits the Wnt pathway by binding to LRP5/6 and subsequently increases bone formation. Sclerostin may also play a role in the mediation of systemic and local factors such as calcitriol, PTH, glucocorticoids and tumor necrosis factor-alpha....

Humor and aging - a mini-review.

Humor is one of the most important human activities, one that is enjoyed daily by people in every culture and at every age. However, very little is known about how aging affects humor experiences. Research suggests that elderly people enjoy humor more than younger people, but they have increasing difficulties in understanding jokes. Several cognitive mechanisms that may help explain this trend ...

Creativity and Aging: a Mini-Literature Review

Evaluation and treatment of erectile dysfunction in the aging male: a mini-review.

Before the 20th century, individuals often did not live beyond the reproductive years, and sexuality of the elderly was not an issue. However, in the current era it is known that as life expectancy improves, both men and women are seeking to preserve their sexuality into old age. While the appreciation of sexuality persists with aging, a decline in sexual activity is typically seen with, and ca...