Reactome enhanced pathway visualization
نویسندگان
چکیده
منابع مشابه
Reactome enhanced pathway visualization
Motivation Reactome is a free, open-source, open-data, curated and peer-reviewed knowledge base of biomolecular pathways. Pathways are arranged in a hierarchical structure that largely corresponds to the GO biological process hierarchy, allowing the user to navigate from high level concepts like immune system to detailed pathway diagrams showing biomolecular events like membrane transport or ph...
متن کاملThe Reactome Pathway Knowledgebase
The Reactome Knowledgebase (https://reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism, and other cellular processes as an ordered network of molecular transformations-an extended version of a classic metabolic map, in a single consistent data model. Reactome functions both as an archive of biological processes and as a tool for discovering u...
متن کاملReactome Pathway Analysis
2 Pathway Enrichment Analysis Enrichment analysis is a widely used approach to identify biological themes. Here, we implement hypergeometric model to assess whether the number of selected genes associated with reactome pathway is larger than expected. We also implement a category net model for viusalization. • Hypergeometric model Hypergeometric model was implemented to assess whether the numbe...
متن کاملReactome graph database: Efficient access to complex pathway data
Reactome is a free, open-source, open-data, curated and peer-reviewed knowledgebase of biomolecular pathways. One of its main priorities is to provide easy and efficient access to its high quality curated data. At present, biological pathway databases typically store their contents in relational databases. This limits access efficiency because there are performance issues associated with querie...
متن کاملReactome: Quick tour
Life at the molecular level is an intricate network of protein interactions and biochemical reactions. A pathway is a small part of this network – a series of connected events, typically characterised by the product or biological outcome. Researchers have defined many biological pathways. These pathways can be accessed via the scientific literature, textbooks, or electronic databases, but the i...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2017
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btx441