Real-time monitoring of enzyme activity in a mesoporous silicon double layer

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Real-time monitoring of enzyme activity in a mesoporous silicon double layer

The activity of certain proteolytic enzymes is often an indicator of disease states such as cancer, stroke and neurodegeneracy, so there is a need for rapid assays that can characterize the kinetics and substrate specificity of enzymatic reactions. Nanostructured membranes can efficiently separate biomolecules, but coupling a sensitive detection method to such a membrane remains difficult. Here...

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ژورنال

عنوان ژورنال: Nature Nanotechnology

سال: 2009

ISSN: 1748-3387,1748-3395

DOI: 10.1038/nnano.2009.11