Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized
نویسندگان
چکیده
منابع مشابه
Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized.
Autocrine ligands are important regulators of many normal tissues and have been implicated in a number of disease states, including cancer. However, because by definition autocrine ligands are synthesized, secreted, and bound to cell receptors within an intrinsically self-contained "loop," standard pharmacological approaches cannot be used to investigate relationships between ligand/receptor bi...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.26.15368