Rebuilding Brain Circuitry with Living Micro-Tissue Engineered Neural Networks
نویسندگان
چکیده
منابع مشابه
Rebuilding Brain Circuitry with Living Micro-Tissue Engineered Neural Networks.
Prominent neuropathology following trauma, stroke, and various neurodegenerative diseases includes neuronal degeneration as well as loss of long-distance axonal connections. While cell replacement and axonal pathfinding strategies are often explored independently, there is no strategy capable of simultaneously replacing lost neurons and re-establishing long-distance axonal connections in the ce...
متن کاملAdvanced biomaterial strategies to transplant preformed micro-tissue engineered neural networks into the brain.
OBJECTIVE Connectome disruption is a hallmark of many neurological diseases and trauma with no current strategies to restore lost long-distance axonal pathways in the brain. We are creating transplantable micro-tissue engineered neural networks (micro-TENNs), which are preformed constructs consisting of embedded neurons and long axonal tracts to integrate with the nervous system to physically r...
متن کاملAnatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling.
Functional recovery rarely occurs following injury or disease-induced degeneration within the central nervous system (CNS) due to the inhibitory environment and the limited capacity for neurogenesis. We are developing a strategy to simultaneously address neuronal and axonal pathway loss within the damaged CNS. This manuscript presents the fabrication protocol for micro-tissue engineered neural ...
متن کاملW3: A Controllable Brain Injury Model with a Defined Size for Evaluation of Tissue Engineered Products
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملTransplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regeneration.
UNLABELLED Neurotrauma, stroke, and neurodegenerative disease may result in widespread loss of neural cells as well as the complex interconnectivity necessary for proper central nervous system function, generally resulting in permanent functional deficits. Potential regenerative strategies involve the recruitment of endogenous neural stem cells and/or directed axonal regeneration through the us...
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2015
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2014.0557