Receptor-mediated Catabolism of Low Density Lipoprotein in Man. QUANTITATION USING GLUCOSYLATED LOW DENSITY LIPOPROTEIN
نویسندگان
چکیده
منابع مشابه
Receptor-mediated low density lipoprotein catabolism in man.
Binding of human low density lipoproteins (LDL) to their specific receptor on cultured cells can be inhibited by treatment with 1,2-cyclohexanedione which blocks a number of functionally significant arginyl residues on the apolipoprotein. We have used this observation to examine the role of the receptor pathway in LDL catabolism in man. The plasma clearance rates of 125I-LDL and 131I-cyclohexan...
متن کاملReceptor-independent Catabolism of Low Density Lipoprotein
In this study we examine the effects of intravenous ethyl oleate emulsions on the metabolism of native and cyclohexanedione-modified human low density lipoprotein in rabbits. Treatment produced a highly significant faU in receptor-independent catabolism as measured by the fractional clearance rate of cyclohexanedione-modified low density lipoprotein. Receptor-dependent Catabolism (the differenc...
متن کاملCatabolism of very low density lipoprotein B apoprotein in man.
The turnover and the catabolic fate of the B apoprotein of very low density lipoprotein (VLDL-B) was studied in 15 normal and hyperlipidemic subjects using reinjected autologous VLDL labeled with radioiodine. The specific radioactivity-time curve of the B apoprotein in total VLDL (S(f)20-400) was multiexponential but conformed to a two-pool model during the first 48 h of catabolism. The flux wa...
متن کاملCatabolism of low density lipoproteins by perfused rabbit livers: Cholestyramine promotes receptor-dependent hepatic catabolism of low density lipoproteins (hepatic low density lipoprotein receptor/low density lipoprotein metabolism/hypercholesterolemia/casein diet/high density lipoprotein
Rabbits fed a wheat starch/casein diet develop a marked hypercholesterolemia accompanied by a decrease in the number of EDTA-sensitive binding sites on plasma membrane fractions of the liver for low density lipoproteins (LDL) and 13migrating very low density lipoproteins [Chao, Y.-S., Yamin, T.T. & Alberts, A. W. (1982)J. BioL Chem., in press]. Inclusion of 1% cholestyramine resin in this diet ...
متن کاملContribution of the receptor pathway to low density lipoprotein catabolism in humans. New methods for quantitation.
Receptor-mediated catabolism of low density lipoprotein (LDL) by cultured cells depends on the presence of functionally significant arginine and lysine residues on the lipoprotein apoprotein. When these are blocked, the recognition process is abolished, and catabolism of the modified lipoprotein is restricted to other mechanisms. Accurate discrimination between the activities of the receptor an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1983
ISSN: 0021-9738
DOI: 10.1172/jci110849