Recognition in action: flipping pyrimidine dimers
نویسندگان
چکیده
منابع مشابه
Pyrimidine dimers in UV-irradiated poly dI:dC.
I Dulbecco, R., and M. Vogt, these PROCEEDINGS, 50, 236 (1963). 2Weil, R., and J. Vinograd, these PROCEEDINGS, 50, 730 (1963). 3 Crawford, L. V., and P. H. Black, Virology, 24, 388 (1964). 4Weil, R., these PROCEEDINGS, 49, 480 (1963). 5 Crawford, L. V., R. Dulbecco, M. Fried, L. Montagnier, and M. Stoker, these PROCEEDINGS, 52, 148 (1964). 6 Winocour, E., Virology, 19, 158 (1963). Murikami, W.,...
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There is increasing evidence that UVA radiation, which makes up approximately 95% of the solar UV light reaching the Earth's surface and is also commonly used for cosmetic purposes, is genotoxic. However, in contrast to UVC and UVB, the mechanisms by which UVA produces various DNA lesions are still unclear. In addition, the relative amounts of various types of UVA lesions and their mutagenic si...
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DNA photolyases that catalyze light-dependent repair of cyclobutane pyrimidine dimers (CPDs) were extracted and partially purified from sorghum and cucumber. The action spectra of CPD photolyases in these plant species had a maximum at 400 nm, which differ from those in Drosophila, Escherichia coli and Anacystis.
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Py pyrimidine dimers Py correndonucleases I and II from Micrococcus luteus act exclusively on thymine-thymine, cytosine-cytosine, and thymine-cytosine cyclobutyl dimers in DNA, catalyzing incision 5' to the damage and generating 3'-hydroxyl and 5'-phosphoryl termini. Both enzymes initiate excision of pyrimidine dimers in vitro by correxonucleases and DNA polymerase I. The respective incised DNA...
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Toluene-treated cells were used for examining excision of pyrimidine dimers in Escherichia coli strains W3110, DM845 (uvrA-), P3478 (polA-), and KS5064 (polAex1). Excision occurring in toluene-treated cells is rapid, adenosine 5'-triphosphate dependent, and requires the uvrA gene function. In strains lacking either the polymerizing or 5' leads to 3' exonucleolytic activity of deoxyribonucleic a...
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ژورنال
عنوان ژورنال: Journal of Molecular Recognition
سال: 2005
ISSN: 0952-3499,1099-1352
DOI: 10.1002/jmr.737