Recombinant Chimeric Western and Eastern Equine Encephalitis Viruses as Potential Vaccine Candidates

Eastern, Western and Venezuelan Equine Encephalomyelitis Sleeping Sickness Eastern Equine Encephalomyelitis (EEE), Eastern Equine Encephalitis, Eastern Encephalitis Western Equine Encephalomyelitis (WEE), Western Equine Encephalitis Venezuelan Equine Encephalomyelitis (VEE), Peste Loca, Venezuelan Equine Encephalitis, Venezuelan Encephalitis, Venezuelan Equine Fever

Eastern equine encephalomyelitis (EEE), western equine encephalomyelitis (WEE), and Venezuelan equine encephalomyelitis (VEE) viruses are mosquito-borne pathogens that can cause nonspecific illnesses and encephalitis in equids (horses, mules, burros, donkeys and zebras) and humans in the Americas. Some of these viruses also affect birds and occasionally other mammals. No specific treatment is a...

Second Generation Inactivated Eastern Equine Encephalitis Virus Vaccine Candidates Protect Mice against a Lethal Aerosol Challenge

Currently, there are no FDA-licensed vaccines or therapeutics for eastern equine encephalitis virus (EEEV) for human use. We recently developed several methods to inactivate CVEV1219, a chimeric live-attenuated eastern equine encephalitis virus (EEEV). Dosage and schedule studies were conducted to evaluate the immunogenicity and protective efficacy of three potential second-generation inactivat...

Eastern Equine Encephalitis Virus

EQUINE ENCEPHALOMYELITIS (Eastern and Western) SUMMARY Eastern and Western equine encephalomyelitis viruses belong to the genus Alphavirus of the family

Eastern and Western equine encephalomyelitis viruses belong to the genus Alphavirus of the family Togaviridae. Alternate infection of birds and mosquitoes maintain these viruses in nature. The disease occurs sporadically in horses and humans from mid-summer to late autumn. Horses and humans are tangential dead-end hosts. The disease in horses is characterised by fever, anorexia, and severe depr...

Comparison of chickens and pheasants as sentinels for eastern equine encephalitis and St. Louis encephalitis viruses in Florida.

Pheasants and chickens were compared as sentinels for monitoring the transmission of arboviruses of public health significance in Florida during 1991-93. Results suggest that pheasants are better sentinels for eastern equine encephalitis (EEE) virus. They detected virus transmission 3-6 weeks earlier in epizootic years, 2-4 times more frequently during the season, and twice as many birds within...