Recurrent seizure-like events are associated with coupled astroglial synchronization

Recurrent seizure-like events are associated with coupled astroglial synchronization

Increasing evidence suggest that astrocytes significantly modulate neuronal function at the level of the tripartite synapse both in physiological and pathophysiological conditions. The global control of the astrocytic syncytium over neuronal networks, however, is still less recognized. Here we examined astrocytic signaling during epileptiform activity which is generally attributed to large-scal...

Cyclothiazide Prolongs Low-[Mg]-Induced Seizure-Like Events

Here we address the effects of cyclothiazide (CTZ), an allosteric inhibitor of alphaamino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor desensitization, on low-[Mg]-induced seizure-like events (SLEs) recorded from the CA3 pyramidal layer of juvenile rat hippocampal slices. CTZ (100 μM) made the period of tonic-like discharges (161 ± 18 % of control) and the whole SLE (151 ± 15 %...

Cyclothiazide prolongs low [Mg2+]-induced seizure-like events.

Here we address the effects of cyclothiazide (CTZ), an allosteric inhibitor of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor desensitization, on low [Mg(2+)]-induced seizure-like events (SLEs) recorded from the CA3 pyramidal layer of juvenile rat hippocampal slices. CTZ (100 microM) made the period of tonic-like discharges (161 +/- 18% of control) and the whole SLE (...

O-7: Y Chromosome Microdeletions Are Not Associated with Spontaneous Recurrent Pregnancy Loss in A Sinhalese Population in Sri Lanka

Background: Many advances have been made in reproductive medicine yet the spontaneous loss of a pregnancy remains the most common complication of pregnancy. The aetiology of spontaneous recurrent pregnancy loss (RPL) is multifactorial. Y chromosome microdeletions are found in approximately 7% of men with low sperm counts and, compared to the general population, a higher frequency of spontaneous...

CD4+CD56+ NKT-like cells secreting interferon-γ are associated with incident coronary events