Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: Consequences for PI3K binding on Gab1
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چکیده
منابع مشابه
Modulation of PDGF Receptor Signaling via the Phosphatase SHP-2 and the Docking Protein Gab1
Kallin, A. 2003. Modulation of PDGF receptor signaling via the phosphatase SHP-2 and the docking protein Gab1. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1300 . 69 pp. Uppsala. ISBN 91-554-5780-0 Platelet-derived growth factors (PDGF) constitute a family of potent mitogens and chemoattractants for cells of mesenchymal origin, wh...
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SHP-2, a ubiquitously expressed Src homology 2 (SH2) domain-containing protein tyrosine phosphatase (PTP), plays a critical role in physiology and disease. SHP-2 has been clearly demonstrated to be an important molecule in various cytoplasmic signal transduction pathways. In addition, emerging evidence indicates that SHP-2 may function in the nucleus and in the mitochondria. However, the signal...
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متن کاملT cell activation is reduced by the catalytically inactive form of protein tyrosine phosphatase SHP-2.
Src-homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is a ubiquitously expressed cytosolic tyrosine phosphatase implicated in many different signaling pathways involving cytokine receptors and T and B cell receptors; however, the precise functional role of SHP-2 in T cell signaling is not entirely clear. In this study, we overexpressed a catalytically inactive form of SHP-2 with a cl...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2006
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2006.03.088