Reduction of proteinuria by angiotensin converting enzyme inhibition

Angiotensin Converting Enzyme in Sarcoidosis

Angiotensin-converting enzyme inhibition by Brazilian plants.

The potential antihypertensive activity of Brazilian plants was evaluated in vitro by its ability to inhibit the angiotensin-converting enzyme (ACE). Forty-four plants belonging to 30 families were investigated. Plants were selected based on their popular use as antihypertensive and/or diuretics. The following plants presented significant ACE inhibition rates: Calophyllum brasiliense, Combretum...

Is proteinuria reduction by angiotensin-converting enzyme inhibition enough to prove its role in renal protection in IgA nephropathy?

I gA nephropathy (IgAN) is the most common biopsy-proven type of glomerulonephritis globally, including children (1). In the United States alone, it is estimated that as many as 30% of children with IgAN are likely to progress to ESRD (2). Most pediatric studies that deal with treatment, prognostic markers, and outcome indicators that are used in clinical trials in IgAN must rely on surrogate m...

Role of Tissue Angiotensin-Converting Enzyme Inhibition

Background Chronic treatment with high doses of angiotensin-converting enzyme (ACE) inhibitors prolongs survival after myocardial infarction. Since the plasma reninangiotensin system (RAS) is not consistently activated in the chronic phase after myocardial infarction, the beneficial effects of ACE inhibition have been attributed, in part, to inhibition of an activated tissue RAS. However, a rel...

Effects of Chronic Angiotensin Converting Enzyme Inhibition

Background. Previous studies have shown that global left ventricular function is depressed after myocardial infarction. However, little is known about the effects of myocardial infarction on contractility and the passive-elastic properties of residual myocardium. Methods and Results. We evaluated isometric function and passive myocardial stiffness in isolated, noninfarcted left ventricular papi...