Reference Range for Serum Parathyroid Hormone

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Radioimmunoassay of human parathyroid hormone in serum.

A new radioimmunoassay for human parathyroid hormone (PTH) in serum, which can measure the hormone present in 94% of the normal sera tested, is described. It is based on the ability of human PTH to compete with (131)I-labeled bovine PTH for binding to an antiserum directed against porcine PTH. This antiserum distinguishes between human PTH extracted from parathyroid adenomata and that present i...

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Measurement of serum parathyroid hormone, with particular reference to some infants with hypocalcaemia.

Fairney, A., Jackson, D., and Clayton, B. E. (1973). Archives of Disease in Childhood, 48, 419. Measurement of serum parathyroid hormone, with particular reference to some infants with hypocalcaemia. Parathyroid hormone (PTH) in serum has been determined by a double antibody radioimmunoassay which is suitable for use in infants. The concentration in normal infants rose after birth from a mean l...

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Conditions for a radioimmunoassay of serum parathyroid hormone.

A radioimmunoassay for parathyroid hormone is described that circumvents some previous difficulties. Parathyroid hormone binds strongly to other serum components. Consequently, a “control” curve is set up for each specimen, the specimen consisting of serum, diluent, and radiolabel, but no antibody. Final calculations are then based on the difference between the control curve and the curve obtai...

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Parathyroid hormone without parathyroid glands.

In mammals, PTH is a component in a complex signaling system involving three structurally related ligands and two G protein-coupled receptors, which share significant amino acid sequence homology (Fig. 1). PTH is a peptide hormone comprising 84 amino acids that is made by the parathyroid glands (and to a much smaller extend by the thymus) and acts through the PTH/PTH-related peptide (PTHrP) rec...

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Thrombin-Mediated Degradation of Parathyroid Hormone in Rapid Serum Tubes

Background: Measurement of parathyroid hormone (PTH) is important for the clinical assessment of parathyroid disease and calcium homeostasis. Previous studies have demonstrated decreased stability of PTH in serum versus plasma specimens, although the precise mechanism for this difference has not been established. If thrombin activation during clot formation is responsible, the effect should be ...

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ژورنال

عنوان ژورنال: Endocrine Practice

سال: 2006

ISSN: 1530-891X

DOI: 10.4158/ep.12.2.137