Regional heritability advanced complex trait analysis for GPU and traditional parallel architectures

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Regional heritability advanced complex trait analysis for GPU and traditional parallel architectures

MOTIVATION Quantification of the contribution of genetic variation to phenotypic variation for complex traits becomes increasingly computationally demanding with increasing numbers of single-nucleotide polymorphisms and individuals. To meet the challenges in making feasible large-scale studies, we present the REgional heritability advanced complex trait analysis software. Adapted from advanced ...

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Advanced Complex Trait Analysis

MOTIVATION The Genome-wide Complex Trait Analysis (GCTA) software package can quantify the contribution of genetic variation to phenotypic variation for complex traits. However, as those datasets of interest continue to increase in size, GCTA becomes increasingly computationally prohibitive. We present an adapted version, Advanced Complex Trait Analysis (ACTA), demonstrating dramatically improv...

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Performance Analysis of CPU-GPU Cluster Architectures

High performance computing (HPC) encompasses advanced computation over parallel processing, enabling faster execution of highly compute intensive tasks such as climate research, molecular modeling, physical simulations, cryptanalysis, geophysical modeling, automotive and aerospace design, financial modeling, data mining and more. High performance simulations require the most efficient compute p...

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Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.

Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with common traits remains unaccounted for within the genome. Genome-wide complex trait analysis (GCTA) is a statistical method that applies a linear mixed model to estimate phenotypic...

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Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis.

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2014

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/btt754