Regulation of c-Jun Phosphorylation by the IκB Kinase-ε Complex in Fibroblast-Like Synoviocytes
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چکیده
منابع مشابه
Secreted frizzled-related protein 5 suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes through down-regulation of c-Jun N-terminal kinase.
OBJECTIVE This study was performed to investigate the effect of secreted frizzled-related protein 5 (Sfrp5), a novel anti-inflammatory adipokine that competes with the frizzled proteins for Wnt binding, on inflammatory response and the c-Jun N-terminal kinase (JNK) signalling pathway in RA. METHODS Expression of Sfrp5 mRNA in peripheral blood mononuclear cells (PBMCs) and fibroblast-like syno...
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Tendon never restores the complete biological and mechanical properties after healing. Several techniques are available for tissue-engineered biological augmentation for tendon healing like stem cells. Recently, synovium has been investigated as a source of cells for tissue engineering. In the present study, we investigated potentials of fibroblast like synoviocytes (FLSs) in tendon healing. Si...
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of the NF-B dimer which then translocates to the nucleus to activate gene transcription. In the case of IB␣ the inducible phosphorylation sites were mapped to ser-ines (S) 32 and 36, whose substitution with alanines (A) or threonines (T) prevents phosphorylation, ubiquitination Summary was recognized that the key step in NF-B activation is IB phosphorylation, much of the effort to understan...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2005
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.174.10.6424