Regulation of plaque stability by p43, cofactor of tRNA synthase, in atherosclerosis

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A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes.

An auxiliary factor of mammalian multi-aminoacyl-tRNA synthetases, p43, is thought to be a precursor of endothelial monocyte-activating polypeptide II (EMAP II) that triggers proinflammation in leukocytes and macrophages. In the present work, however, we have shown that p43 itself is specifically secreted from intact mammalian cells, while EMAP II is released only when the cells are disrupted. ...

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Cell death-mediated cleavage of the attraction signal p43 in human atherosclerosis: implications for plaque destabilization.

OBJECTIVE Apoptosis is a key feature of advanced atherosclerotic plaques. Attraction signals such as p43 released from apoptotic cells play a crucial role in the timely removal of the apoptotic remnants by recruiting fresh phagocytes. Here, we sought to determine whether p43 may link apoptosis to inflammation and plaque progression. METHODS AND RESULTS RT-PCR and immunohistochemistry showed t...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2002

ISSN: 0735-1097

DOI: 10.1016/s0735-1097(02)81107-x