Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: Effect of ursodeoxycholate
نویسندگان
چکیده
منابع مشابه
Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver.
BACKGROUND/AIMS The hepatic clearance of drugs and cholephilic organic anions is stimulated by phenobarbital (PB). Our aim was to analyze the effects of PB on the expression of hepatocellular bile salt and organic anion transporters. METHODS Male Sprague-Dawley rats were treated intraperitoneally with PB (80 mg/kg/d) or saline for 5 days. Transporter expression was quantified by northern and ...
متن کاملEndocrine regulation of rat organic anion transporters.
Messenger RNA levels of rat organic anion transporter 1 (Oat1; Slc22a6) and Oat2 (Slc22a7) in kidney and Oat3 (Slc22a8) in liver are gender-predominant. Oat1 and Oat3 are male-predominant, whereas Oat2 is female-predominant. Gonadectomized and hypophysectomized (HX) rats were studied to determine whether sex steroids and/or growth hormone (GH) are responsible for these gender-divergent patterns...
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15 صفحه اولBile salt transporters: molecular characterization, function, and regulation.
Molecular medicine has led to rapid advances in the characterization of hepatobiliary transport systems that determine the uptake and excretion of bile salts and other biliary constituents in the liver and extrahepatic tissues. The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSE...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2003
ISSN: 0270-9139
DOI: 10.1053/jhep.2003.50256