Regulation of tRNA‐dependent translational quality control
نویسندگان
چکیده
منابع مشابه
Co-translational mechanisms of quality control of newly synthesized polypeptides
During protein synthesis, nascent polypeptides emerge from ribosomes to fold into functional proteins. Misfolding of newly synthesized polypeptides (NSPs) at this stage leads to their aggregation. These misfolded NSPs must be expediently cleared to circumvent the deleterious effects of protein aggregation on cell physiology. To this end, a sizable portion of NSPs are ubiquitinated and rapidly d...
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متن کاملMechanism of tRNA-dependent editing in translational quality control.
Protein synthesis requires the pairing of amino acids with tRNAs catalyzed by the aminoacyl-tRNA synthetases. The synthetases are highly specific, but errors in amino acid selection are occasionally made, opening the door to inaccurate translation of the genetic code. The fidelity of protein synthesis is maintained by the editing activities of synthetases, which remove noncognate amino acids fr...
متن کاملThe physiological target for LeuRS translational quality control is norvaline.
The fidelity of protein synthesis depends on the capacity of aminoacyl-tRNA synthetases (AARSs) to couple only cognate amino acid-tRNA pairs. If amino acid selectivity is compromised, fidelity can be ensured by an inherent AARS editing activity that hydrolyses mischarged tRNAs. Here, we show that the editing activity of Escherichia coli leucyl-tRNA synthetase (EcLeuRS) is not required to preven...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2019
ISSN: 1521-6543,1521-6551
DOI: 10.1002/iub.2080