Relationship of Thrombospondin-1 and Thrombospondin-2 with hematological, biochemical and inflammatory markers in COVID-19 patients

Abstract Objectives Roles of Thrombospondin-1 (TSP-1) and Thrombospondin-2 (TSP-2) in tissue repair inflammation are well-documented, but the association their serum expressions with pathogenesis COVID-19 remains unclear. We investigate roles TSP-1 TSP-2 COVID-19. Methods 106 SARS-CoV-2 infected patients 23 healthy people were enrolled our study. divided into two groups as non-severe severe. concentrations measured an enzyme-linked Immunosorbent Assay, blood markers analyzed routine laboratory techniques. Results had significantly higher levels than controls. positively correlated inflammatory markers, including ESR, CRP, PCT, ferritin, biochemical parameters such ALT, AST, BUN, CK, LDH. In addition, negatively hematological LYM, EOS, HGB. Receiver operating characteristic analyses revealed that may be predicted over 189.94 ng/mL 0.70 ng/mL. Conclusions Our analysis suggests at systemic level have clinical importance for