Release factors differing in specificity for terminator codons.
نویسندگان
چکیده
منابع مشابه
Release factors differing in specificity for terminator codons.
In a previous paper, initiator and terminator trinucleotides were shown to stimulate sequentially the binding of f-Met-tRNA to ribosomes and the release of free f-methionine from the ribosomal intermediate.1 The formation of f-methionine was dependent upon a terminator codon, such as UGA, UAA, or UAG, and the release factor R discovered by Capecchi.2 The separation of R into two components is d...
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Modified trinucleotides, 3MeU-A-G+, 3MeU-A-A, 5MeUA-G, 5MeU-A-A, BrU-A-G, hU-A-G, and U-A-I (see J. BioZ. Chem., 241, 527 (1966)), were synthesized by a combination of organic and enzymatic methods. The activity of each trinucleotide as a template for peptide chain termination was determined. The attachment of a methyl group to the NB position of uracil eliminates the template activity of termi...
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15 صفحه اولPolypeptide release at sense and noncognate stop codons by localized charge-exchange alterations in translational release factors.
The mechanism of stop codon recognition during translation has long been a puzzle. Only recently has it been established that a tripeptide in the bacterial release factors (RFs) 1 and 2 serves as the "anticodon" in deciphering stop codons in mRNA. However, the molecular basis of the accuracy of stop codon recognition is unknown. Although specific tripeptides in the RFs are primarily responsible...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1968
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.61.2.768