Release of lysosomal hydrolases during simulated extracorporeal circulation
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چکیده
منابع مشابه
Thromboxane synthesis and platelet protein release during simulated extracorporeal circulation.
Platelet secretion induced by certain soluble aggregating agents is associated with thromboxane formation. Activation of platelets by artificial surfaces may involve similar biochemical pathways. Therefore. we monitored platelet release and formation of thromboxane B2. the stable endproduct of thromboxane A2, during simulated extracorporeal circulation where contact between blood and synthetic ...
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Certain forms of extracorporeal circulation exemplified by cardiopulmonary bypass require continuous high-dose anticoagulation to prevent thromboembolic complications. We hypothesized that monocytes may be stimulated to express tissue factor (TF) during prolonged simulated extracorporeal circulation. TF was identified both by flow cytometry by using three TF-specific monoclonal antibodies and f...
متن کاملPhysicochemical modifications of lysosomal hydrolases during intracellular transport.
1. The following fractions were prepared from rat kidney and characterized ultrastructurally, biochemically and enzymically: (a) an ordinary rough microsomal (RM(1)) fraction; (b) a special rough microsomal (RM(2)) fraction enriched seven- to nine-fold in acid hydrolases over the homogenate; (c) a smooth microsomal (SM) fraction; (d) a Golgi (GM) fraction enriched 2.5-fold in acid hydrolases an...
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Introduction: Tracheal chondrosarcoma (TCS) is a rare malignancy, with only 19 cases described in the literature to date. Case presentation: Herein, we presented the third-largest TCS with such an airway compromise that neither orotracheal intubation nor jet ventilation or even tracheostomy was possible. So, extracorporeal circulation was needed to excise the tumor in a one-stage procedure. Th...
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BACKGROUND Neutrophil is a major focus in efforts to ameliorate the systemic inflammatory response associated with cardiopulmonary bypass. Neutrophil elastase is a powerful proteolytic enzyme, and plays a pivotal role in the development of the inflammatory response. This study assesses the inhibitory effects of sivelestat, a highly specific neutrophil elastase inhibitor, on elastase levels, cyt...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1982
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)39511-x