Renal Biomarker combinations predict early CRRT need in a mixed ICU population

Background: Acute kidney injury (AKI) is associated with markedly increased morbidity and mortality in critically ill patients often necessitates the use of continuous renal replacement therapy (CRRT). The aim present study was to compare predictive performance urine neutrophil gelatinase (uNGAL), plasma cystatin C (pCysC), serum creatinine (sCr), their combinations for CRRT requirement within first 7 days post-admission a general ICU.Method material: A total 81 consecutive ICU were included analysis. AKI defined according AKIN criteria. Biomarkers’ abilities evaluated by area under receiver operating characteristics (AUC-ROC) curves.Results Conclusions: occurred 21% 14% them needed post-admission. two novel biomarkers, as well sCr had moderate requirement. most efficient (sCr+ uNGAL) (sCr+uNGAL+pCysC) better AUC-ROCs (0.845 0.84, respectively) than that any individual biomarker (sCr, pCysC, uNGAL, 0.81, 0.74 0.80, respectively). Renal need one week post admission compared each alone.