Renal dysfunction in patients with pulmonary embolism: data from the SIRENA register

Aim. To assess the prevalence, severity and prognostic value of renal dysfunction (RD) in patients with pulmonary embolism (PE) Russian population, as well to determine RD significance a marker that improves predictive ability current risk stratification systems. Material methods. From April 2018 2019, hospitalized due PE were sequentially included multicenter observational prospective registry SIRENA. was diagnosed at glomerular filtration rate (GFR) <60 ml/ min/1,73 m 2 . Risk early (hospital or 30-day) death stratified accordance 2019 ESC Clinical Guidelines. During study, we analyzed inpatient mortality complication rate. Results. A total 604 (men, 293 (49%); women, 311 (51%)) study. detected 320 (53%) patients, while severe — 63 (10%) ones. In addition, 71 (12%) had high risk, 364 (61%) intermediate, 164 (27%) low. hospitalization, 107 (18%) died, including 32% from high-risk group, 20% moderate, 7% deceased more often, GFR <50 ml/min/1,73 reliably predicted hospital (sensitivity, 67%; specificity, 72%; AUC=0,72; p<0,001). simplified Pulmonary Embolism Severity Index (sPESI) 0 ≥ 1, presence led least 2-fold increase mortality. Multivariate Cox regression revealed is predictor in-hospital (hazard ratio (HR), 3,41; 95% confidence interval (CI): 2,15-5,41; p<0,001), regardless reclassifies, such troponin (HR, 1,31; CI: 0,80-2,14; p=0,28) right ventricular 1,23; 0,74-2,04; p=0,42). Conclusion. there incidence RD, which every second patient 10% cases. The associated significant mortality, increases decrease GFR. addition considered estimated , sPESI allows identification death.