Repeat-Associated MicroRNAs Trigger Fragile X Mental Retardation-Like Syndrome in Zebrafish~!2008-10-29~!2008-11-12~!2008-11-26~!
نویسندگان
چکیده
منابع مشابه
Repeat-Associated MicroRNAs Trigger Fragile X Mental Retardation- Like Syndrome in Zebrafish
A new class of repeat-associated microRNA (ramRNA) is identified to hinder normal brain development in zebrafish. Previous studies have shown that small hairpin RNAs derived from the 5’-untranslational CGG/CCG trinucleotide repeat [r(CGG)] expansion of fragile X mental retardation gene 1, FMR1, may cause neuronal toxicity in fragile X mental retardation syndrome (FXS). However, their roles in F...
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The majority of the human genome is comprised of non-coding DNA, which frequently contains redundant microsatellite-like trinucleotide repeats. Many of these trinucleotide repeats are involved in triplet repeat expansion diseases (TREDs) such as fragile X syndrome (FXS). After transcription, the trinucleotide repeats can fold into RNA hairpins and are further processed by Dicer endoribonuclases...
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Persons with mental retardation represent 1 to 2% of the worldwide population. Due to their suggestive behavior and ingenuousness, these persons tend to be vulnerable to violence in all its forms. Nevertheless, difficulties concerning impulse control and lack of judgment contribute to disruptive and maladaptive behaviors in some of them. These misbehaviors may include sexual violence, thefts, p...
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The fragile X mental retardation syndrome in humans is caused by a mutational loss of function of the fragile X mental retardation gene 1 (FMR1). FMR1 is an RNA-binding protein, involved in the development and function of the nervous system. Despite of its medical significance, the evolutionary origin of FMR1 has been unclear. Here, we report the molecular characterization of HyFMR1, an FMR1 or...
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Fragile X syndrome is the most common form of inherited mental retardation in humans, with an estimated prevalence of about 1 in 4000 males. Although several observations indicate that the absence of functional Fragile X Mental Retardation Protein (FMRP) is the underlying basis of Fragile X syndrome, the structure and function of FMRP are currently unknown. Here, we present an X-ray crystal str...
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ژورنال
عنوان ژورنال: The Open Neuropsychopharmacology Journal
سال: 2008
ISSN: 1876-5238
DOI: 10.2174/1876523800801010006