Reply to Keller and Springborn: No doubt about invasion debt

Doubt about antidepressant-like effect

Dear Editor: Extensive studies have measured antidepressant-like effects of chemical compounds to discover new drugs for depression treatment or to clarify the molecular mechanisms of depression. Most useful anti-depressants including tricyclics, selective serotonin reuptake inhibitors (SSRIs), noradrenaline reuptake inhibitors (NRIs), serotonin and noradrenaline re-uptake inhibitors (SNRIs), a...

No doubt about the validity of the urine test for detection of recombinant human erythropoietin.

Letter: Clarifying doubt about endocrine-related science.

February 18, 2016 Professor Gio Batta Gori Editor, Regulatory Toxicology and Pharmacology, 525B Street, Suite 1900, San Diego, CA 92101-4495, USA. Professor Gori, We are writing on behalf of four associations to express our regret and concern regarding the comments made towards the crop protection industry in the December 2015 commentary by Bergman et al. (2015) entitled “Manufacturing Doubt Ab...

Nitric oxide production by human macrophages: there's NO doubt about it.

THE DISCOVERY OF NITRIC OXIDE (NO) production from L-arginine by NO synthases has revolutionized our understanding of many aspects of human physiology. Since the seminal studies of Furchgott and Zawadzki (7), tremendous progress has been made in understanding the regulation of vascular tone by NO. Novel pharmacological agents based on the circulatory actions of NO have already found widespread ...

Doubts about ‘uncertainty without All the Doubt’

Call the following the storage hypothesis : degreed beliefs are stable attitudes of agents that can be appealed to for predicting and explaining patterns of behavior, judgment, and decision making. [1] the storage hypothesis is that humans have, or it is as if we have, degrees of belief, and our judgment and decision making across a wide range of situations is systematically predicted by them (...