Repressive translational control in germ cells
نویسندگان
چکیده
منابع مشابه
Transient translational quiescence in primordial germ cells.
Stem cells in animals often exhibit a slow cell cycle and/or low transcriptional activity referred to as quiescence. Here, we report that the translational activity in the primordial germ cells (PGCs) of the sea urchin embryo (Strongylocentrotus purpuratus) is quiescent. We measured new protein synthesis with O-propargyl-puromycin and L-homopropargylglycine Click-iT technologies, and determined...
متن کاملTitle : “ Vasa and translational control in the Drosophila germ line ”
The Drosophila protein Vasa (VAS) is essential maternally for posterior patterning and germ cell specification. In the developing ovary and embryo, VAS is mostly present in germline RNPs, a general term for large cytoplasmic ribonucleoprotein particles such as nuage particles and polar granules. These particles, and VAS specifically, are involved in localizing and regulating translation from as...
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Translational control is a prevalent form of gene expression regulation in the Caenorhabditis elegans germ line. Linking the amount of protein synthesis to mRNA quantity and translational accessibility in the cell cytoplasm provides unique advantages over DNA-based controls for developing germ cells. This mode of gene expression is especially exploited in germ cell fate decisions and during oog...
متن کاملPositive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity
Ultimately, the production of new proteins in undetermined cells pushes them to new fates. Other proteins hold a stem cell in a mode of self-renewal. In germ cells, these decision-making proteins are produced largely from translational control of preexisting mRNAs. To date, all of the regulation has been attributed to RNA binding proteins (RBPs) that repress mRNAs in many models of germ cell de...
متن کاملpiRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells.
Transposable elements (TEs) occupy a large fraction of metazoan genomes and pose a constant threat to genomic integrity. This threat is particularly critical in germ cells, as changes in the genome that are induced by TEs will be transmitted to the next generation. Small noncoding piwi-interacting RNAs (piRNAs) recognize and silence a diverse set of TEs in germ cells. In mice, piRNA-guided tran...
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ژورنال
عنوان ژورنال: Molecular Reproduction and Development
سال: 2013
ISSN: 1040-452X
DOI: 10.1002/mrd.22161