Reprogramming of Cardiac Repolarization
نویسندگان
چکیده
منابع مشابه
Molecular physiology of cardiac repolarization.
The heart is a rhythmic electromechanical pump, the functioning of which depends on action potential generation and propagation, followed by relaxation and a period of refractoriness until the next impulse is generated. Myocardial action potentials reflect the sequential activation and inactivation of inward (Na(+) and Ca(2+)) and outward (K(+)) current carrying ion channels. In different regio...
متن کاملReprogramming for cardiac regeneration
Treatment of cardiovascular diseases remains challenging considering the limited regeneration capacity of the heart muscle. Developments of reprogramming strategies to create in vitro and in vivo cardiomyocytes have been the focus point of a considerable amount of research in the past decades. The choice of cells to employ, the state-of-the-art methods for different reprogramming strategies, an...
متن کاملDispersion of repolarization in cardiac resynchronization therapy.
BACKGROUND Proarrhythmic effects of cardiac resynchronization therapy (CRT) as a result of increased transmural dispersion of repolarization (TDR) induced by left ventricular (LV) epicardial pacing in a subset of vulnerable patients have been reported. The possibility of identifying these patients by ECG repolarization indices has been suggested. OBJECTIVES The purpose of this study was to te...
متن کاملModelling the molecular basis of cardiac repolarization.
AIMS To study the properties of ion-channel gating (I(Ks), the slow delayed rectifier K+ channel) that underlie the channel's participation in rate-dependent repolarization of the cardiac action potential (AP). METHODS Computational biology approach was used to simulate the channel gating and the AP of a mammalian ventricular myocyte. RESULTS At fast rate, channels accumulate at closed stat...
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Heart disease is one of the lead causes of death worldwide. Many forms of heart disease, including myocardial infarction and pressure-loading cardiomyopathies, result in irreversible cardiomyocyte death. Activated fibroblasts respond to cardiac injury by forming scar tissue, but ultimately this response fails to restore cardiac function. Unfortunately, the human heart has little regenerative ab...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2016
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.116.310156