reSETting chromatin during transcription elongation
نویسندگان
چکیده
منابع مشابه
Transcription Elongation: TLKing to Chromatin?
Tousled-like kinases (TLKs) have important functions during the cell cycle in eukaryotes. The TLK family was named after its founding member, the product of the TOUSLED gene which is essential for normal development of the plant Arabidopsis thaliana [1]. More recently, these kinases have been implicated in deposition of chromatin following DNA replication. During S phase, nucleosomes must be as...
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Transcriptional elongation requires the concerted action of several factors that allow RNA polymerase II to advance through chromatin in a highly processive manner. In order to identify novel elongation factors, we performed systematic yeast genetic screening based on the GLAM (Gene Length-dependent Accumulation of mRNA) assay, which is used to detect defects in the expression of long transcrip...
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1Departamento de Genética, Facultad de Bioloǵıa, Universidad de Sevilla, Seville 41012, Spain 2Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA 3Laboratoire de Genetique Moleculaire, Academie Universitaire Louvain, 5000 Namur, Belgium 4Departamento de Bioloǵıa Molecular, Instituto de Parasitoloǵıa y Biomedicina “...
متن کاملTranscription within condensed chromatin: Steric hindrance facilitates elongation.
During eukaryotic transcription, RNA-polymerase activity generates torsional stress in DNA, having a negative impact on the elongation process. Using our previous studies of chromatin fiber structure and conformational transitions, we suggest that this torsional stress can be alleviated, thanks to a tradeoff between the fiber twist and nucleosome conformational transitions into an activated sta...
متن کاملThe Role of Chromatin during Transcription
Chromatin structure imposes significant obstacles on all aspects of transcription that are mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated through multiple mechanisms including histone modification, chromatin remodeling, histone variant incorporation, and histone eviction. In this Review, we highlight advances in our understanding of chromatin regulation...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2013
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.23333