Resolving the relationships of resolving enzymes
نویسندگان
چکیده
منابع مشابه
Resolving the relationships of resolving enzymes.
H junction-resolving enzymes are metal ion-dependent endonucleases that recognize and cleave four-way DNA junctions arising during recombination (reviewed in ref. 1). Examples include RuvC in eubacteria (2, 3), Cce1 in fungal mitochondria (4), Hjc in archaea (5, 6), and three enzymes in bacteriophage [RusA (7), T4 endonuclease VII (8), and T7 endonuclease I (9, 10)]. These six nucleases display...
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Four-way DNA (Holliday) junctions are resolved into duplex species by the action of the junction-resolving enzymes, nucleases selective for the structure of helical branchpoints. These have been isolated from bacteria and their phages, archaea, yeasts and mammals, including humans. They are all dimeric proteins that bind with high selectivity to DNA junctions and generate bilateral cleavage wit...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.97.17.9351