Responses of the sustained inward current to autonomic agonists in guinea-pig sino-atrial node pacemaker cells
نویسندگان
چکیده
منابع مشابه
Pacemaker mechanism of porcine sino-atrial node cells.
In cardiac sino-atrial node (SAN) cells, time- and voltage-dependent changes in the gating of various ionic currents provide spontaneous, stable and repetitive firing of action potentials. To address the ionic nature of the species-dependent heart rate, action potentials and membrane currents were recorded in single cells dissociated from the porcine SAN, and compared with those from SAN cells ...
متن کاملSustained inward current during pacemaker depolarization in mammalian sinoatrial node cells.
Several time- and voltage-dependent ionic currents have been identified in cardiac pacemaker cells, including Na(+) current, L- and T-type Ca(2+) currents, hyperpolarization-activated cation current, and various types of delayed rectifier K(+) currents. Mathematical models have demonstrated that spontaneous action potentials can be reconstructed by incorporating these currents, but relative con...
متن کاملResponses of the sino-atrial node to change in pressure in the sinus node artery.
The sino-atrial node area was perfused selectively through the right atrial artery in 76 dogs. The relationship between changes in the blood pressure in this artery and sinus node rhythmicity was studied in 56 hearts in which the major blood supply to the sinus node artery came from the right atrial artery. A reciprocal relation was observed between changes of blood pressure in the sinus node a...
متن کاملMinor contribution of cytosolic Ca transients to the pacemaker rhythm in guinea pig sinoatrial node cells
Yukiko Himeno, Futoshi Toyoda, Hiroyasu Satoh, Akira Amano, Chae Young Cha, Hiroshi Matsuura, and Akinori Noma Department of Diabetes and Clinical Nutrition, Faculty of Medicine, Kyoto University, Kyoto; Department of Physiology, Faculty of Medicine, Shiga University of Medical Science, Shiga; Department of Pharmacology, Faculty of Medicine, Nara Medical University, Nara; and Department of Bios...
متن کاملMinor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells.
The question of the extent to which cytosolic Ca(2+) affects sinoatrial node pacemaker activity has been discussed for decades. We examined this issue by analyzing two mathematical pacemaker models, based on the "Ca(2+) clock" (C) and "membrane clock" (M) hypotheses, together with patch-clamp experiments in isolated guinea pig sinoatrial node cells. By applying lead potential analysis to the mo...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2005
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706101