Restricted Access: the Transition Zone Controls Ciliary Composition and Signaling
نویسندگان
چکیده
منابع مشابه
Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance.
Cilia are thought to harbour a membrane diffusion barrier within their transition zone (TZ) that compartmentalises signalling proteins. How this "ciliary gate" assembles and functions remains largely unknown. Contrary to current models, we present evidence that Caenorhabditis elegans MKS-5 (orthologue of mammalian Mks5/Rpgrip1L/Nphp8 and Rpgrip1) may not be a simple structural scaffold for anch...
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The protein nephrocystin-4 (NPHP4) is widespread in ciliated organisms, and defects in NPHP4 cause nephronophthisis and blindness in humans. To learn more about the function of NPHP4, we have studied it in Chlamydomonas reinhardtii. NPHP4 is stably incorporated into the distal part of the flagellar transition zone, close to the membrane and distal to CEP290, another transition zone protein. The...
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Yogesh P. Wairkar,1 Hirofumi Toda,2,3 Hiroaki Mochizuki,3 Katsuo Furukubo-Tokunaga,3 Toshifumi Tomoda,2 and Aaron DiAntonio1 1Department of Developmental Biology, Washington University in St. Louis, St. Louis, Missouri 63110, 2Division of Neurosciences, Beckman Research Institute of the City of Hope, Duarte, California 91010, and 3Graduate School of Life and Environmental Sciences, University o...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2015
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.29.1_supplement.78.2