RET mutated C-cells proliferate more rapidly than non-mutated neoplastic cells
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چکیده
منابع مشابه
Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults.
NK cells are essential for health, yet little is known about human NK turnover in vivo. In both young and elderly women, all NK subsets proliferated and died more rapidly than T cells. CD56(bright) NK cells proliferated rapidly but died relatively slowly, suggesting that proliferating CD56(bright) cells differentiate into CD56(dim) NK cells in vivo. The relationship between CD56(dim) and CD56(b...
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متن کاملPrimary RET-mutated lung neuroendocrine carcinoma in MEN2B: response to RET-targeted therapy.
Multiple endocrine neoplasias (MENs) are genetic syndromes distinguished by specific patterns of benign and malignant tumors of endocrine glands. MEN2 is caused by autosomal dominant inheritance of a gain-of-function mutation in the RET proto-oncogene on chromosome 10 (Mulligan & Ponder 1995, Santoro et al. 1995) and is further subclassified into three syndromes based on clinical phenotype: MEN...
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ژورنال
عنوان ژورنال: Endocrine Connections
سال: 2021
ISSN: 2049-3614
DOI: 10.1530/ec-20-0589