Retinal light damage: Protective effect of α-tocopherol
نویسندگان
چکیده
منابع مشابه
The protective effect of ascorbic acid in retinal light damage of rats exposed to intermittent light.
Retinal light damage in dark-reared rats supplemented with ascorbic acid and exposed to multiple doses of intermittent light was studied and compared with damage in unsupplemented dark-reared and cyclic-light-reared rats. The extent of photoreceptor cell loss from intense light exposure was determined by whole-eye rhodopsin levels and retinal DNA measurements two weeks after light treatment. Tw...
متن کاملProtective effect of halothane anesthesia on retinal light damage: inhibition of metabolic rhodopsin regeneration.
PURPOSE To determine whether the volatile anesthetic halothane protects against light-induced photoreceptor degeneration in the rodent retina. METHODS Albino mice and rats were anesthetized with halothane and exposed to high levels of white or blue light. Nonanesthetized animals served as controls. Retinal morphology was assessed by light microscopy, and apoptosis of photoreceptor cells was v...
متن کاملThe protective effect of ascorbate in retinal light damage of rats.
Cyclic light and dark-reared rats were exposed to intense visible light for various periods and then rhodopsin-measured following recovery in darkness for up to 14 days. Animals were injected with ascorbic acid or ascorbate derivatives at various doses prior to light exposure in green Plexiglas chambers. The results show that ascorbic acid administration elevates retinal ascorbate and reduces t...
متن کاملProtective effect of TEMPOL derivatives against light-induced retinal damage in rats.
PURPOSE OT-551 (1-hydroxy-4-cyclopropanecarbonyloxy-2,2,6,6-tetramethylpiperidine hydrochloride), a TEMPOL-H (OT-674) derivative, is a new catalytic antioxidant. In the present study, the efficacy of OT-551 and OT-674 in retinal neuroprotection was tested in a model of light-induced photoreceptor degeneration. METHODS Albino rats were intraperitoneally injected with OT-551, OT-674, or water, ...
متن کاملProtective Effects of α-Tocopherol against Brain Tissue Damage Induced by Intracerebral Hemorrhage in SD Rats
Lipid peroxidation mediated by oxygen radical is one of the main mechanisms underlying secondary brain injury. Among all vitamin E compounds, α-tocopherol shows the most prominent antioxidative effects. It plays an important role in cell aging and injury. However, there has been no report regarding the effects of α-tocopherol on changes in brain tissue morphology after intracerebral hemorrhage ...
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ژورنال
عنوان ژورنال: Japanese Journal of Ophthalmology
سال: 1997
ISSN: 0021-5155
DOI: 10.1016/s0021-5155(97)00034-8