Retraction Note: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus
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Retraction: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus
Most low GC Gram-positive bacteria possess an essential walKR two-component system (TCS) for signal transduction involved in regulating cell wall homoeostasis. Despite the well-established intracellular regulatory mechanism, the role of this TCS in extracellular signal recognition and factors that modulate the activity of this TCS remain largely unknown. Here we identify the extracellular recep...
متن کاملRefutation: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus
peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not .
متن کاملCorrespondence: Spontaneous secondary mutations confound analysis of the essential two-component system WalKR in Staphylococcus aureus
Supplementary Figure 1: Impact of DHBP on lysostaphin induced lysis. No enhanced impact on lysostaphin induced lysis in S. aureus strain Newman was observed when grown in the presence of 75 µM DHBP. Error bars depict the range from three independent experiments.
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The response to cationic antimicrobial peptides (CAMPs) in Staphylococcus aureus relies on a two-component system (TCS), GraSR, an auxiliary protein GraX and an ATP-binding cassette (ABC) transporter, VraF/G. To understand the signal transduction mechanism by GraSR, we investigated the kinase activity of the cytoplasmic domain of histidine kinase GraS and the interaction with its cognate respon...
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Our previous studies suggested that the essential two-component signal transduction system, YhcSR, regulates the opuCABCD operon at the transcriptional level, and the Pspac-driven opuCABCD partially complements the lethal effects of yhcS antisense RNA expression in Staphylococcus aureus. However, the reason why yhcSR regulon is required for growth is still unclear. In this report, we present th...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/ncomms14331