Revealing evolutionary constraints on proteins through sequence analysis
نویسندگان
چکیده
منابع مشابه
Quaternary structure constraints on evolutionary sequence divergence.
The structurally constrained protein evolution (SCPE) model simulates protein divergence considering protein structure explicitly. The model is based on the observation that protein structure is more conserved during evolution than the sequences encoding for that structure. In the previous work, the SCPE model considered only the tertiary structure. Here we show that the performance of the mode...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2019
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1007010