Revealing hemodynamic heterogeneity of gliomas based on signal profile features of dynamic susceptibility contrast-enhanced MRI
نویسندگان
چکیده
منابع مشابه
Dynamic susceptibility contrast MRI
Introduction Quantitative dynamic susceptibility contrast perfusion MRI (DSC-MRI) is based on the monitoring of the first passage of a bolus of contrast agent through the brain tissue and a brain-feeding artery. The contrast agent is injected rapidly by means of an MRinjector in the antecubital vein in the patients arm and a saline flush is used to push the contrast agent into the direction of ...
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Dynamic contrast-enhanced MRI is becoming a standard tool for imaging-based trials of anti-vascular/angiogenic agents in cancer. So far, however, biomarkers derived from DCE-MRI parameter maps have largely neglected the fact that the maps have spatial structure and instead focussed on distributional summary statistics. Such statistics-e.g., biomarkers based on median values-neglect the spatial ...
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Introduction Gliomas are the most common primary brain tumours [1-3]. New blood vessels formation leading to increased microvascular density (MVD) and breakdown in blood brain barrier (BBB) are hallmarks for malignancy in gliomas that can readily be probed by imaging. Perfusion MRI has shown added value over standard contrast enhanced MRI that is sensitive to BBB breakdown [4]. It is unclear wh...
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BACKGROUND Dynamic contrast-enhanced MRI (DCE-MRI) estimates vascular permeability of brain tumors, and susceptibility-weighted imaging (SWI) may demonstrate tumor vascularity by intratumoral susceptibility signals (ITSS). This study assessed volume transfer constant (Ktrans) accuracy, the volume of extravascular extracellular space (EES) per unit volume of tissue (Ve) derived from DCE-MRI, and...
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The purpose of this research is to perform automated analysis of 4D dynamic contrast enhanced MRI datasets (DCE-MRI) of the hand and wrist relating to rheumatoid arthritis (RA) studies. In DCE-MRI, sequences of images are acquired from the joints over time, during which a contrast agent pre-injected into a patient enhances disease affected tissues. Measurement of this enhancement, which is spec...
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ژورنال
عنوان ژورنال: NeuroImage: Clinical
سال: 2019
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2019.101864