Reversibility of Hemodynamic Hypofrontality in Schizophrenia
نویسندگان
چکیده
منابع مشابه
Sensorimotor gating deficits and hypofrontality in schizophrenia.
Patients with schizophrenia exhibit (a) deficient sensorimotor gating as indexed by impaired prepulse inhibition (PPI) of the startle eyeblink reflex suggesting abnormal automatic information processing and (b) abnormal attentional modulation of PPI suggesting impaired controlled information processing. Here we test the hypothesis of deficient attentional modulation of PPI in schizophrenia as a...
متن کاملHypofrontality in schizophrenia: a meta-analysis of functional imaging studies.
OBJECTIVE Hypofrontality is not a well-replicated finding in schizophrenia either at rest or under conditions of task activation. METHOD Studies comparing whole brain and frontal blood flow/metabolism in schizophrenic patients and normal controls were pooled. Voxel-based studies were also combined to examine the pattern of prefrontal activation in schizophrenia. RESULTS Whole brain flow/met...
متن کاملSpeculation on the meaning of cerebral metabolic hypofrontality in schizophrenia.
Cerebral metabolic hypofrontality in schizophrenia is a controversial research finding. In this article we discuss some of the issues that fuel this controversy, and we speculate on the neural mechanisms that may be responsible for the finding. Most regional cerebral blood flow (rCBF) studies using radioactive xenon have found hypofrontality; the results of positron emission tomography (PET) st...
متن کاملNeurocognitive Expression of Hypofrontality in Long Term Schizophrenia
Despite over a century of studies on schizophrenia, its pathogenesis still remains unexplained. In particular, cognitive dysfunctions, related to a decrease of prefrontal cortex activity in the human brain represent one of the main symptoms of schizophrenia. The cognitive dysfunctions usually precede, by a few years, the first acute episode of the disease. These dysfunctions are present in appr...
متن کاملBeyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia.
Although there is considerable evidence that patients with schizophrenia fail to activate the dorsolateral prefrontal cortex (DLPFC) to the degree seen in normal comparison subjects when performing working memory or executive tasks, hypofrontality may be coupled with relatively increased activity in other brain regions. However, most imaging studies of working memory in schizophrenia have focus...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 1987
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.1987.2