Reversible Glutathionylation Regulates Actin Polymerization in A431 Cells
نویسندگان
چکیده
منابع مشابه
How Wasp Regulates Actin Polymerization
Protrusion of lamellipodia and filopodia from the cell surface requires that actin polymerize locally. Actin polymerization is initiated by numerous agonists, including growth factors, chemoattractants, extracellular matrix, and phagocytic particles. The signaling pathways from the corresponding receptors converge on Rho family GTPases, especially Rac and Cdc42, which induce actin polymerizatio...
متن کاملReversible polymerization and ultracentrifugal purification of actin.
Actin is the second major structure protein of muscle. It is characterized by its ability to combine with myosin and to occur in two forms, globular and fibrous actin (9, 10, 3), which are indicated as Gand Factin. The transition of Ginto F-actin is brought about by addition of salt at neutral or weakly alkaline reaction (9, 10, 4). The present paper describes a method of purifying actin by pre...
متن کاملGlutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1.
Embryonic development depends on complex and precisely orchestrated signaling pathways including specific reduction/oxidation cascades. Oxidoreductases of the thioredoxin family are key players conveying redox signals through reversible posttranslational modifications of protein thiols. The importance of this protein family during embryogenesis has recently been exemplified for glutaredoxin 2, ...
متن کاملVaccinia virus regulates expression of p21WAF1/Cip1 in A431 cells.
In this paper, we provide evidence that both the mRNA and protein levels of the cyclin-dependent kinase (CDK) inhibitor p21WAF1/CDK-interacting protein 1 (Cip1) increase upon infection of A431 cells with Vaccinia virus (VACV). In addition, the VACV growth factor (VGF) seems to be required for the gene expression because infection carried out with the mutant virus VACV-VGF- revealed that this st...
متن کاملActin filament polymerization regulates gliding motility by apicomplexan parasites.
Host cell entry by Toxoplasma gondii depends critically on actin filaments in the parasite, yet paradoxically, its actin is almost exclusively monomeric. In contrast to the absence of stable filaments in conventional samples, rapid-freeze electron microscopy revealed that actin filaments were formed beneath the plasma membrane of gliding parasites. To investigate the role of actin filaments in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.c100415200