Reversible Inactivation of the Tumor Suppressor PTEN by H2O2
نویسندگان
چکیده
منابع مشابه
Reversible inactivation of the tumor suppressor PTEN by H2O2.
The tumor suppressor PTEN regulates cell migration, growth, and survival by removing the 3'-phosphate of phosphoinositides. Exposure of purified PTEN or of cells to H(2)O(2) resulted in inactivation of PTEN in a time- and H(2)O(2) concentration-dependent manner. Analysis of various cysteine mutants, including mass spectrometry of tryptic peptides, indicated that the essential Cys(124) residue i...
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Phosphatase and tensin homologue deleted from chromosome ten (PTEN) is a lipid phosphatase tumor suppressor that is lost or inactivated in most human tumors. The enzyme catalyzes the hydrolysis of phosphatidylinositol-(3,4,5)-trisphosphate (PIP3) to form phosphatidylinositol-(4,5)-bisphosphate (PIP2) and inorganic phosphate. Here, we report on the first continuous assay for the catalytic activi...
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Suppressor Gene Ralf Lesche, Matthias Groszer, Jing Gao, Ying Wang, Albee Messing, Hong Sun, Xin Liu, and Hong Wu* Howard Hughes Medical Institute and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California Department of Pathobiological Sciences, Waisman C...
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BACKGROUND PTEN is a tumor suppressor gene that regulates the PTEN/PI3k/AKT/mTOR pathway, which is frequently altered in human cancers including gallbladder cancer (GBC). To determine the frequency of PTEN expression in GBC and to establish its relation to clinical and morphological parameters and survival in GBC. METHODS The immunohistochemical expression of PTEN was studied in 108 GBC. All ...
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background: in 1997 mmac1 or the pten gene, was identified as a tumor suppressor gene on the long arm of chromosome 10.pten involves in the balance between proliferation, and differentiation, apoptosis and regulation of angiogenesis, and eventually mutation in this gene causes a strong potential for tumorigenesis cells. this study is the first report of the correlation between pten gene mutatio...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m111899200