Reversion of Cold-Adapted Live Attenuated Influenza Vaccine into a Pathogenic Virus

Pan-Influenza A Protection by Prime–Boost Vaccination with Cold-Adapted Live-Attenuated Influenza Vaccine in a Mouse Model

Influenza virus infections continually pose a major public health threat with seasonal epidemics and sporadic pandemics worldwide. While currently licensed influenza vaccines provide only strain-specific protection, antigenic drift and shift occasionally render the viruses resistant to the host immune responses, which highlight the need for a vaccine that provides broad protection against multi...

Adverse events reported following live, cold-adapted, intranasal influenza vaccine.

CONTEXT In June 2003, the US Food and Drug Administration licensed a trivalent live, attenuated influenza vaccine (LAIV-T) for intranasal administration to healthy persons 5 to 49 years of age. Although prelicensure testing involved 20 228 vaccinees, clinical trials were not of sufficient size to detect rare adverse events reliably. OBJECTIVE To identify adverse events reported following LAIV...

Development of an Attenuated Live Virus Vaccine against Sheep Pox

Small-particle aerosolization of live attenuated influenza vaccine virus.

To the Editor—In their recent study, Bischoff et al [1] exposed subjects to a small-particle aerosol of commercially available live attenuated influenza vaccine (LAIV; MedImmune LLC, Gai-thersburg, MD). LAIV was used as a proxy for wild-type influenza to evaluate the protection provided by N95 respirators, surgical masks, and eye protection. Although the study addresses the important question o...

Live attenuated influenza vaccine--a review.

Owing to the variability of influenza viruses, vaccine composition needs to be up-dated annually. As many variables can influence their efficacy, vaccines are still considered "sub-optimal". Many studies have been carried out in recent years to improve vaccines. In particular, researchers and vaccine-producing corporations have focused on developing a live vaccine. Among the candidate vaccines,...