Revisiting Anti-tuberculosis Activity of Pyrazinamide in Mice
نویسندگان
چکیده
منابع مشابه
Revisiting Anti-tuberculosis Activity of Pyrazinamide in Mice
The mechanism of action of pyrazinamide, a key sterilizing drug in the treatment of tuberculosis, remains elusive; pyrazinamide is a pro-drug that requires activation by a bacterial-encoded enzyme, and its activity is most apparent on non-replicating Mycobacterium tuberculosis. Recently, it has been suggested that pyrazinamide might exert also some host-directed effect in addition to its antimi...
متن کاملHost Targeted Activity of Pyrazinamide in Mycobacterium tuberculosis Infection
Pyrazinamide (PZA) is one of the first line antibiotics used for the treatment of tuberculosis (TB). In the present study, we have used in vitro and in vivo systems to investigate whether PZA, in addition to its known anti-mycobacterial properties, modulate the host immune response during Mycobacterium tuberculosis (Mtb) infection. In vitro we have examined the effect of PZA on cytokine and che...
متن کاملActivity of 5-chloro-pyrazinamide in mice infected with Mycobacterium tuberculosis or Mycobacterium bovis
BACKGROUND & OBJECTIVES Pyrazinamide is an essential component of first line anti-tuberculosis regimen as well as most of the second line regimens. This drug has a unique sterilizing activity against Mycobacterium tuberculosis. Its unique role in tuberculosis treatment has lead to the search and development of its structural analogues. One such analogue is 5-chloro-pyrazinamide (5-Cl-PZA) that ...
متن کاملActivity of pyrazinamide in the guinea pig model of tuberculosis.
Ordway et al. (8) have recently evaluated standard chemotherapy with a combination of rifampin, isoniazid, and pyrazinamide (PZA) in the guinea pig model of tuberculosis (TB) and described long-term bacterial persistence. Soon after the introduction of PZA in 1952, perhaps the most experienced group examining the activity of antituberculosis drugs in the guinea pig model reported that PZA had l...
متن کاملThe effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis - insights for early bactericidal activity?
BACKGROUND Pyrazinamide (PZA) plays an essential part in the shortened six-month tuberculosis (TB) treatment course due to its activity against slow-growing and non-replicating organisms. We tested whether PZA preferentially targets slow growing cells of Mycobacterium tuberculosis that could be representative of bacteria that remain after the initial kill with isoniazid (INH), by observing the ...
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ژورنال
عنوان ژورنال: Mycobacterial Diseases
سال: 2014
ISSN: 2161-1068
DOI: 10.4172/2161-1068.1000145