RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors

Zizimin and Dock guanine nucleotide exchange factors in cell function and disease

Zizimin proteins belong to the Dock (Dedicator of Cytokinesis) superfamily of Guanine nucleotide Exchange Factor (GEF) proteins. This family of proteins plays a role in the regulation of Rho family small GTPases. Together the Rho family of small GTPases and the Dock/Zizimin proteins play a vital role in a number of cell processes including cell migration, apoptosis, cell division and cell adhes...

A High-Throughput Assay for Rho Guanine Nucleotide Exchange Factors Based on the Transcreener GDP Assay.

Ras homologous (Rho) family GTPases act as molecular switches controlling cell growth, movement, and gene expression by cycling between inactive guanosine diphosphate (GDP)- and active guanosine triphosphate (GTP)-bound conformations. Guanine nucleotide exchange factors (GEFs) positively regulate Rho GTPases by accelerating GDP dissociation to allow formation of the active, GTP-bound complex. R...

Authority in the Dock

The dock problem revisited

The dock problem (cf. [2], [4, 5]), which is that of understanding the scattering of surface water waves by a thin semi-infinite rigid plate floating on the free surface of water of infinite depth, gives rise to the following mixed boundary value problem, involving Laplace’s equation in two dimensions, with (x, y) representing the rectangular Cartesian coordinates, assuming linearised theory of...

The finite dock problem

The scattering of water waves by a dock of finite width and infinite length in water of finite depth is solved using the modified residue calculus technique. The problem is formulated for obliquely incident waves and the case of normal incidence is recovered by taking an appropriate limit. Exciting forces and pitching moments are calculated as well as reflection and transmission coefficients. T...