Rhodanine and Thiohydantoin Derivatives for Detecting Tau Pathology in Alzheimer’s Brains
نویسندگان
چکیده
منابع مشابه
Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice
Filamentous tau aggregates are hallmark lesions in numerous neurodegenerative diseases, including Alzheimer's disease (AD). Cell culture and animal studies showed that tau fibrils can undergo cell-to-cell transmission and seed aggregation of soluble tau, but this phenomenon was only robustly demonstrated in models overexpressing tau. In this study, we found that intracerebral inoculation of tau...
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ژورنال
عنوان ژورنال: ACS Chemical Neuroscience
سال: 2011
ISSN: 1948-7193,1948-7193
DOI: 10.1021/cn200002t