Risk Factors for Elevated D-Dimer Levels in Patients with Gastrointestinal Tumors Treated with Endoscopic Submucosal Dissection

Endoscopic submucosal dissection (ESD) is almost always performed with a sedative because of the longer procedure times involved. The risk post-ESD deep vein thrombosis (DVT) has been reported as relatively high, and D-dimer levels are sometimes elevated after ESD. This retrospective study evaluated factors affecting changes in from before to ESD identify causes analysis included 117 patients gastrointestinal tumors resected using After excluding eight pre-ESD >1.5 μg/mL, correlating were analyzed logistic regression 109 patients. Sedation was accomplished primarily midazolam, but, effect midazolam shows marked inter-individual variability, “corrected dose” determined by dividing total dose initial correct for differences midazolam. value used one potential explanatory variable subgroup 103 who received In corrected an variable, only correlated change ≥1.0 μg/mL multivariate (odds ratio (OR) = 1.5, 95% confidence interval (CI) 0.43–0.95; p 0.030). increases levels. relationship indicates that undergoing requiring extended sedation may be at increased DVT.