RNA-binding protein Sam68 controls synapse number and local -actin mRNA metabolism in dendrites
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چکیده
منابع مشابه
RNA-binding protein Sam68 controls synapse number and local β-actin mRNA metabolism in dendrites.
Proper synaptic function requires the spatial and temporal compartmentalization of RNA metabolism via transacting RNA-binding proteins (RBPs). Loss of RBP activity leads to abnormal posttranscriptional regulation and results in diverse neurological disorders with underlying deficits in synaptic morphology and transmission. Functional loss of the 68-kDa RBP Src associated in mitosis (Sam68) is a...
متن کاملDepolarization-induced translocation of the RNA-binding protein Sam68 to the dendrites of hippocampal neurons.
The traffic and expression of mRNAs in neurons are modulated by changes in neuronal activity. The regulation of neuronal RNA-binding proteins is therefore currently receiving attention. Sam68 is a ubiquitous nuclear RNA-binding protein implicated in post-transcriptional processes such as signal-dependent splice site selection. We show that Sam68 undergoes activity-responsive translocation to th...
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It is now widely accepted that mRNAs localize to dendrites and that translation of these mRNAs is regulated in response to neuronal activity. Recent studies have begun to reveal the underpinnings of these processes and to underscore the importance of local protein synthesis to synaptic remodeling and plasticity. When Steward and Levy (1982) first reported their observation of polyribosomes at t...
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that RNA-binding proteins recognize specific secondary Most cells are heterogeneous entities in which specific structures in the 39 UTR, forming complexes that are regions are specialized for particular functions, as rethen transported along microtubules. For example, in flected by the uneven distribution of intracellular organDrosophila, the double-stranded RNA-binding protein elles. Neurons a...
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The quaking viable (qk(v)) mice represent an animal model of dysmyelination. The absence of expression of the QKI-6 and QKI-7 cytoplasmic isoforms in oligodendrocytes (OLs) during CNS myelination causes the qk(v) mouse phenotype. The QKI RNA-binding proteins are known to regulate RNA metabolism of cell cycle proteins and myelin components in OLs; however, little is known of their role in reorga...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1209811110