RNA binding to p62 impacts selective autophagy
نویسندگان
چکیده
منابع مشابه
Structural basis for sorting mechanism of p62 in selective autophagy.
Impairment of autophagic degradation of the ubiquitin- and LC3-binding protein "p62" leads to the formation of cytoplasmic inclusion bodies. However, little is known about the sorting mechanism of p62 to autophagic degradation. Here we identified a motif of murine p62 consisting of 11 amino acids (Ser334-Ser344) containing conserved acidic and hydrophobic residues across species, as an LC3 reco...
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Autophagy is a highly conserved bulk protein degradation pathway responsible for the turnover of long-lived proteins, disposal of damaged organelles, and clearance of aggregate-prone proteins. Thus, inactivation of autophagy results in cytoplasmic protein inclusions, which are composed of misfolded proteins and excess accumulation of deformed organelles, leading to liver injury, diabetes, myopa...
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RATIONALE Recent studies suggest an important role of autophagy in protection against αB-crystallin-based (CryAB(R120G)) desmin-related cardiomyopathies (DRC), but this has not been demonstrated in a different model of cardiac proteinopathy. Mechanisms underlying the response of cardiomyocytes to proteotoxic stress remain incompletely understood. OBJECTIVE Our first objective was to determine...
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Type 2 diabetes (T2D) and cancer are two common diseases with tremendous impact on health worldwide. Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well as certain diabetic risk factors and diabetic medications. Generally, hyperinsulinemia and high level of circulating Insulin-like growth factor 1 (IGF-1) contribute to cancer development through the insulin...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2019
ISSN: 1001-0602,1748-7838
DOI: 10.1038/s41422-019-0167-2