RNA interference silencing of DRAL affects processing of amyloid precursor protein
نویسندگان
چکیده
منابع مشابه
RNA interference silencing of DRAL affects processing of amyloid precursor protein.
In a previous study, we reported that Alzheimer's disease-associated presenilin-2 interacts with a LIM-domain protein, namely, DRAL/FHL2/SLIM3. In this study, we investigated whether DRAL modifies the metabolism of the amyloid precursor protein (APP). We used small interfering RNA (siRNA) to knockdown DRAL in COS7 and HEK293 cells that stably overexpress APP695. We found that the knockdown was ...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2008
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2008.05.039