Robust analysis of secondary phenotypes in case-control genetic association studies
نویسندگان
چکیده
منابع مشابه
Efficient adaptively weighted analysis of secondary phenotypes in case-control genome-wide association studies.
We propose and compare methods of analysis for detecting associations between genotypes of a single nucleotide polymorphism (SNP) and a dichotomous secondary phenotype (X), when the data arise from a case-control study of a primary dichotomous phenotype (D), which is not rare. We considered both a dichotomous genotype (G) as in recessive or dominant models and an additive genetic model based on...
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Secondary trait genetic association provides insight into the genetic architecture of disease etiology but requires caution in estimation. Ignoring case-control sampling may introduce bias into secondary trait association. In this paper, we compare the efficiency and robustness of various inverse probability weighted (IPW) estimators andmaximum likelihood (ML) estimators. ML methods have been p...
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Secondary trait genetic association provides insight into the genetic architecture of disease etiology but requires caution in estimation. Ignoring case-control sampling may introduce bias into secondary trait association. In this paper, we compare the efficiency and robustness of various inverse probability weighted (IPW) estimators and maximum likelihood (ML) estimators. ML methods have been ...
متن کاملTitle Robust Tests for Case-control Genetic Association Studies
May 10, 2010 Type Package Title Robust tests for case-control genetic association studies Version 1.03 Date 2010-05-10 Author Yong ZANG , Wingkam FUNG , Gang ZHENG Maintainer Yong ZANG Depends R (>= 2.6.0), mvtnorm Description This package supplies several robust tests for case-control genetic association studies. The te...
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Case-control association studies use genetic markers as putative etiologic risk factors. The approach is controversial and has tended to produce associations in neuropsychiatry that do not stand the test of time. We studied the processes that can bias the outcomes away from a true representation of the relationship between a genetic marker and a neuropsychiatric disorder. If conducted with care...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2016
ISSN: 0277-6715
DOI: 10.1002/sim.6976