Role of Bacterial and Host DNases on Host-Pathogen Interaction during Streptococcus suis Meningitis

Chromatin Remodelling During Host-Bacterial Pathogen Interaction

Host-pathogen Interaction at the Intestinal Mucosa Correlates With Zoonotic Potential of Streptococcus suis

BACKGROUND Streptococcus suis has emerged as an important cause of bacterial meningitis in adults. The ingestion of undercooked pork is a risk factor for human S. suis serotype 2 (SS2) infection. Here we provide experimental evidence indicating that the gastrointestinal tract is an entry site of SS2 infection. METHODS We developed a noninvasive in vivo model to study oral SS2 infection in pig...

Bacterial outer membrane vesicles and the host-pathogen interaction.

Extracellular secretion of products is the major mechanism by which Gram-negative pathogens communicate with and intoxicate host cells. Vesicles released from the envelope of growing bacteria serve as secretory vehicles for proteins and lipids of Gram-negative bacteria. Vesicle production occurs in infected tissues and is influenced by environmental factors. Vesicles play roles in establishing ...

Streptococcus suis Meningitis, Hawaii

with advanced TB may occur, given the endemic nature of TB in humans in Nigeria (10). TB cases caused by EAI strains have been found in humans in southwestern Nigeria (4; S.I. Cadmus et al., unpub. data), a fi nding that supports zoonotic transmission of this organism from humans to goats. However, different lineages of M. tuberculosis may vary in host range, and EAI genotype strains may be ada...

Bacterial antigenic variation, host immune response, and pathogen-host coevolution.

Many bacterial pathogens are exquisitely adapted to host parasitization. Their niche is primarily determined by the biochemical milieu of the host. As such, pathogens are selected to exhibit environmentally responsive and adaptive molecular traits which allow adherence, entrance, and replication within the host (7, 26). One major set of selective forces which operates to shape the phenotype of ...