Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity
نویسندگان
چکیده
منابع مشابه
Urinary glutathione-S-transferase in cisplatin nephrotoxicity in the rat.
Rats given a single toxic dose of cisplatin all developed detectable glutathione-S-transferase activity in their urine between the third and fifth day after injection of cisplatin, simultaneously with the decreased urine osmolality and increased urine volume characteristic of cisplatin nephrotoxicity. Peak urinary glutathione-S-transferase levels occurred at the same time as maximal serum creat...
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SUMMARY Cisplatin is a widely used anticancer agents that is effective against ovarian and other tumors. This drug is recognized as nephrotoxic in human and experimental animals. The effect of cisplatin-induced kidney injury was predominantly investigated in male animals. This study was designed to assess effects of cisplatin on male and female rat kidneys. We also investigated the effect of g...
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Nephrotoxicity of chemotherapeutics is a major hindrance in the treatment of various tumors. Therefore, test systems that reflect mechanisms of human kidney toxicity are necessary, and to reduce animal testing cell culture based systems have to be developed. One cell type that is of specific interest in this regard are renal proximal tubular epithelial cells, as they reabsorb substances from hu...
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Class-Pi of glutathione s-transferases (GST-Pi) is the specific form of GSTs that are known to participate particularly in the mechanisms of resistance to drugs and carcinogens. This class of the enzyme is referred to as class-P or class-Pi or class π. The accepted terminology in this review article is class-Pi. In this article following a brief description of identified molecular forms of GSTs...
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1. Eight rats developed detectable glutathione-S-transferase activity in their urine after three daily injections of toxic doses of gentamicin. 2. Seven of the eight rats had immunodetectable ligandin in their urine at this time. 3. The level of enzyme activity correlated well with the degree of elevation of serum creatinine. 4. This confirms ligandinuria and urinary glutathione-S-transferase a...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2009
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2008.08.004