Role of HIF-1α in Alcohol-Mediated Multiple Organ Dysfunction
نویسندگان
چکیده
منابع مشابه
The Relationship between Plasma Levels of Interleukin-6, Multiple Organ Dysfunction and Mortality in Orthopedic Patients
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4 Abstract: At physiological oxygen concentrations ([O2]) hypoxia-inducible factor-1α (HIF-1α) is constantly hydroxylated and thus prepared for proteosomal degradation through the action of the prolyl hydroxylases (PHDs) (Jiang et al., 1996). In hypoxia, however, the oxygen-sensitive PHDs are inhibited and HIF-1α is stabilised. Other agents, including cytokines and growth factors have been show...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2018
ISSN: 2218-273X
DOI: 10.3390/biom8040170